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Series of Assessments to Guide Evaluation

Assess patient symptoms quickly, comprehensively and at low cost.

The SAGE is a streamlined battery of psychological tests which screen for a current episode of up to 30 diagnoses. The tests can be administered independently or in combination. Results are clinically valid and are compatible with international behavioral health diagnostic standards (DSM-5 and ICD-11).

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Administer quick, comprehensive screenings by self-report.
Easy and intuitive to use, the SAGE tests ask a series of questions written at fifth-grade reading level. The self-report version (SAGE-SR) is web-based and can be taken in the waiting room or from home using an e-mailed link. The screening tests take about 6 to 12 minutes to complete.  The follow up diagnostic tests take an additional 0 to 20 minutes to complete, depending on systems endorsed. The clinician interview version (SAGE-CI) is currently in development, and will be a highly structured interview which can be administered by any primary care clinician.

A rigorous diagnostic report is immediately available.
Instant user-friendly reports provide a differential diagnosis (SR) or specific diagnosis (CI) with ICD-10 codes for the clinician. Clinicians can send interpretive reports immediately to the patient’s EHR. SAGE reports enable clinicians to delve deeper in face-to-face appointments, researchers to make important decisions, and pharmaceutical companies to recruit more precisely for trials.

Track client change and progress over time.
Clinicians can decide how often they would a client to take follow-up assessments. The follow-ups include a subset of questions from each module that show the change over time for certain symptoms. Clients only see questions which they received in the initial SAGE, so follow-up assessments take only a few minutes. The clinician will then receive a report showing the change in severity for each initial diagnosis.

“We are currently using the SAGE-SR to screen participants for six ongoing clinical trials. The SAGE-SR diagnostic system is quick, easy-to-use, and convenient.”

Dr. Joseph Alcorn III, PhD, Postdoctoral Fellow
Laboratory of Human Behavioral Pharmacology (LHBP)
College of Medicine, University of Kentucky


Affective Disorders

  • Major Depressive Episode
  • Manic Episode
  • Hypomanic Episode
  • Persistent Depressive Disorder
  • Major Depressive Disorder
  • Other Specified Depressive Disorder
  • Bipolar I Disorder
  • Bipolar II Disorder
  • Other Specified Bipolar Disorder

Anxiety Disorders

  • Panic Disorder
  • Agoraphobia
  • Social Anxiety Disorder
  • Generalized Anxiety Disorder
  • Obsessive‐Compulsive Disorder
  • Post-Traumatic Stress Disorder
  • Adult Attention-Deficit/Hyperactivity Disorder (ADHD)

Psychotic Disorders

  • Schizophrenia
  • Schizophreniform Disorder
  • Schizoaffective Disorder
  • Delusional Disorder
  • Brief Psychotic Disorder
  • Other Specified Psychotic Disorder

Alcohol & Substance Use Disorders

  • Alcohol Use Disorder
  • Cannabis Use Disorder
  • Inhalant Use Disorder
  • Other Hallucinogen Use Disorder
  • Opioid Use Disorder
  • Phencyclidine Use Disorder
  • Sedative/Hypnotic/Anxiolytic Use Disorder
  • Stimulant Use Disorder
  • Other/Unknown Substance Use Disorder

SAGE Features

  • Highly configurable module selection
  • Rigorous differential diagnoses
  • Computer-adaptive system reduces administration time and increases diagnostic specificity
  • Real-time diagnostic reporting
  • Secure HIPAA-compliant database
  • Accessible Symptom-level Data
  • Customizable permission access structure
  • EHR Integration available



SAGE-SR (Self-Report)

The SAGE-SR is the world’s first completely self-report comprehensive diagnostic assessment compatible with both the ICD-10 and the DSM-5. Written at a 5th-grade reading level, consisting of 70 short screening questions, and containing no open-ended questions, the SAGE-SR is user-friendly both for the client taking the assessment and the clinician. Individual assessments take 10 to 20 minutes for your client, depending upon the number of screening questions endorsed, and little to no clinician time. No clinician training is required for administration.

If a client meets the screening threshold in any category, that group of screening questions branches to a more comprehensive set of self-report questions. The total item bank consists of over 500 items, yet no patient receives more than 100 of these follow-up items.

Clinicians can administer the SAGE in waiting rooms, or send secure links for clients to take the assessment from home using a PC, Tablet, or smartphone. To protect your client and your practice, the SAGE-SR runs via a secure, cloud-based server, and it does not include any items relating to suicide or homicide.

The SAGE-SR covers all diagnostic symptoms of 30 behavioral health diagnoses. Intuitive reports provide feedback on pertinent positive endorsements and a list of ICD-10 diagnoses that should be considered, which are compatible with DSM. It is up to the clinician to evaluate pertinent positives and to draw her own conclusion about diagnoses.  Clinicians can, as an option, drill down using the report to view the patient’s responses to all items.  Reports are available immediately on-line and in many instances can be sent directly to the client’s EHR.

SAGE-CI (Clinician Interview)


For those interested in a deeper evaluation of the patient’s diagnoses, we will offer the SAGE-CI, a highly structured interview that can be administered by any primary care clinician. The SAGE-CI can stand on its own, prompting clinicians to ask questions in a structured interview, or it can build upon the SAGE-SR and pre-populate with the patient’s self-report responses, saving the clinician time and allowing the clinician more control over follow-up questions and interpretation.

Either way, the SAGE-CI is intuitive to use. Administration can usually be mastered in about 15 minutes and requires no in-person training. Individual assessments take 10 to 20 minutes depending upon the number of screening questions endorsed.

The resulting SAGE-CI report provides the clinician a specific diagnosis with relevant ICD-10 codes. These interpretive clinical reports can be sent immediately to the patient’s EHR in a user-friendly format. Patients can read their reports online or print them out before a clinician visit.



Rapid and Accurate Behavioral Health Diagnostic Screening: Initial Validation Study of a Web-Based, Self-Report Tool (SAGE-SR). Benjamin Brodey, MPH, MD; Susan E Purcell, PhD; Karen Rhea, MD; Philip Maier, BS; Michael First, MD; Lisa Zweede, MD; Manuela Sinisterra, BA; M Brad Nunn, PhD; Marie-Paule Austin, MD, Franx C.P.; Inger S Brodey, PhD. Journal of Medical Internet Research  (2018)


Validation of the SAGE-SR: A Self-Report Diagnostic Assessment Based on the DSM-5 and SCID Designed to Improve the Signal-to-Noise-Ratio in Clinical Trials. Benjamin B. Brodey, MD, MPH and Lisa Zweede, MD, MS.

How can the SAGE advance research and clinical work?

Explore a wide range of symptoms quantitatively and at minimal cost: The SAGE promotes accurate diagnosis and ensures that co-occurring disorders are properly identified, generating appropriate ICD-10 codes.

Quickly identify patients who might be eligible to participate in specific clinical trials: Since a detailed analysis of symptoms will be included in a searchable database, the SAGE will enable researchers quickly to identify patients who might be eligible to participate in specific clinical trials.

Identify symptoms that are most likely to improve with a specific intervention: The SAGE may make it possible to identify the symptom clusters that are associated with a good response to specific interventions.  It may also help identify the symptoms that are most likely to improve with a specific intervention.

Identify symptom clusters most commonly associated with specific biomarkers: Once a very large database exists, the SAGE will also make it possible to search the symptom database to identify the symptom clusters most commonly associated with specific biomarkers.

Sign up online to administer the SAGE.


Behavioral Health Diagnoses and Outcomes
Chapel Hill, North Carolina 27514 | USA

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